Severe acquired brain injury (SABI) is a damage to the brain, occurring from traumatic (TBI) or non-traumatic causes, and resulting in deterioration of physical, cognitive, and emotional functioning. SABI rehabilitation should be as intensive and long as to allow the patients get the best independence and quality of life (QoL), but facing with the rehabilitation socio-economic burden. Telerehabilitation (TR) could supply frail subjects requiring long term rehabilitation. We will investigate the use of TR, based on advanced Information and Communication Technology (ICT) solutions, taking into account that the supervision of rehabilitation at home will be enriched with the counselling and vital parameters monitoring. We aim to evaluate that TR is at least non-inferior in comparison with the same amount of usual territorial rehabilitative physical treatments (UTRT), taking into account patients’ functional recovery, psychological well-being, caregiver burden, and healthcare costs.